This work presents a self adhesive soft flexible styrene-isoprene (SIS) electrode for a wearable bio-signal acquisition device. This novel dry electrode is made with an ink composed of SIS dissolved in toluene and embedded with silver (Ag) particles. Their applicability for surface bioelectronic signal acquisition is reviewed and compared to 3M medical grade gel electrodes. These sensors show a skin-electrode interface impedance of less than 30 kOhm at 10 kHz which is comparable to standard gel electrodes. Inspired by the setal stalks that geckos use to adhere to surfaces, these electrodes’ are patterned with vertically aligned micropillars that, through contact splitting, allow the electrode to adhere to human skin without the need for glue. These microstructures have also been designed to help the electrode acquire bio-potentials even in the presence of contaminating particles or other foreign objects at the interface between the skin and electrode that otherwise would affect the skin-electrode impedance and the quality of the signal being acquired. Together, these characteristics make the soft, microstructured electrodes well-suited for wearable bio-signal acquisition devices that can be re-used or applied to skin that has dirt or other contamination.