This studying provides a combined method between three-dimensional digital image correlation optical method (3D DIC) and finite element method (FEM) to develop the simulation methodology under the twistable physical behavior. The experiment instrument has been designed to provide the physical deformation to simulate various twistable angle for daily application field of flexible hybrid electronics (FHE). In this studying, an innovative technology on noncontact capacitive coupling-based sensor system of FHE has been applied in biological signal measurement combined with both electrocardiographic (ECG) and electromyographic (EMG). Firstly, capacitive coupling-based sensor device with high sensitivity and resistance has been designed to overcome the weakness of traditional impedance sensor such as signal noise interference and uncomfortable feeling because of traditional design. In addition, by considering the application field of FHE under daily activity, mechanical simulation with FEM has been developed to deal with each different physical deformation especially twistable behavior. The twistable behavior has been regarded as the complex physical behavior. To validate FEM, the experiment instrument has been developed to generate various physical deformation from twistable angle. Furthermore, combined with full-field surface deformations measured from 3D DIC, it has been applied to validate simulation results. The specification of 3D DIC has been included two 5-megapixel cameras and visible range around 40 mm width and 60 mm length. Final, for the system verification, measurement platform of noncontact capacitive coupling-based sensor has been established and successful demonstrated with biological signal detecting of EMG and ECG. Based on simulation results, it has been summarized that design flows involved dense cooper trace and the floorplan of FHE. In addition, flexible packaging technology has been utilized to enhance the fit feeling of FHE and diminish the stress at critical connection joints. Polydimethylsiloxane (PDMS) has been applied in flexible packaging technology, which provided with biocompatibility, ductility and transparency. Through plasma treatment, the interface between PDMS and FPC has been improved. In conclusion, ITRI innovative achievement related to the noncontact capacitive coupling-based sensor FHE, which passed the biaxial twistable test under 10,000 times and kept the stability of electrical signal with more than 30 db signal to noise ratio (SNR).